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Promising safety profile: Early trials report tolerability comparable to incretin-based agents, though higher doses are associated with GI side effects (nausea, diarrhea, vomiting, constipation) Clinical Advantage over Others (Clinical Trial Evidence) Phase 2 obesity studies: At 48 weeks, retatrutide delivered weight reductions up to 24%, far exceeding results reported for monotherapy GLP-1 agents

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In the brain, GLP-1 therapies support mitochondrial energy balance, proteostasis, and synaptic resilience —mechanistic counterweights to the processes that drive cognitive decline